METHOD OF TREATMENT OF SPINAL CORD INJURY WITH RESTORATION OF ITS FUNCTIONS WITH NEURO-PEG PEG-CHITOSAN CONJUGATE Russian patent published in 2023 - IPC A61B17/00 G09B23/28 A61K31/722 A61K31/745 A61P25/00 

FIELD: medicine; experimental medicine; neurosurgery; regenerative medicine.

SUBSTANCE: invention can be used to treat spinal cord injury with restoration of its functions with a PEG-chitosan conjugate. The synthesis of PEG-chitosan is carried out by covalent binding of PEG with photocrosslinked chitosan. After access to the spinal cord, transpedicular screws are installed in the vertebral bodies above and below the injury site, spondylotomy is performed using one of the methods, the dura and pia mater are opened, and the spinal cord is cooled with an ice slurry from sterile saline. The PEG-chitosan conjugate preparation synthesized by the covalent binding method is injected into the subdural space. The spinal cord is transected and resected within the viable part, followed by the introduction of the PEG-chitosan conjugate into the subdural space and the spinal cord diastasis in the amount required to cover the surface of the spinal cord segments and fill the diastasis. The maximum dorsal traction of the spine is performed to create dorsal flexion in the spondylotomy zone, and the transpedicular system is finally fixed. Close approach of segments of the spinal cord is performed, dura mater is sutured, an intravenous injection of an aqueous solution of polyethylene glycol is performed, and in the postoperative period, intramuscular injections of trypsin and neuromyoelectric stimulation are used.

EFFECT: method ensures the restoration of the functional and morphological integrity of the spinal cord after its intersection, as well as in case of its contusion and rupture due to the use of a PEG-chitosan conjugate together with surgical comparison of spinal cord segments, as well as subtraction spondylotomy with transpedicular fixation and postoperative administration of trypsin and polyethylene glycol.

1 cl, 2 dwg