METHOD OF REPLACEMENT SELENOTHERAPY IN SEPTIC ENCEPHALOPATHY Russian patent published in 2023 - IPC A61K33/04 A61K31/43 A61K9/08 A61K31/137 A61K31/435 A61K31/616 A61K31/4365 A61K38/38 A61K38/28 A61K31/4439 A61P31/00 

FIELD: medicine; resuscitation.

SUBSTANCE: invention can be used for the treatment of septic encephalopathy in the acute period. On the second day after the diagnosis of sepsis, the patient is administered in parallel with the complex of intensive etiopathogenetic therapy for sepsis, the following: meropenem (antibiotic) — 2 g 3 times a day for 15 days; infusion therapy with sterofundin — 1,500 ml a day as IV drip; ambroxol — 2 ml 3 times a day as inhalation; ipratropium bromide — 2 ml 4 times a day for 9 days; thrombo ACC — 100 mg a day orally; clopidogrel — 75 mg once daily orally; human albumin 10% — 100 ml as IV drip once daily; low molecular weight heparin fraxiparin — 0.6 ml s/c; haloperidol — 5 mg twice daily, 2 days; norepinephrine, vasoactive support — 0.15 mcg/kg/min as IV by the dispenser; biosulin for correction of hyperglycemia — s/c 3 times a day; omeprazole for prevention of stress ulcers of the gastrointestinal tract — 20 mg orally 1 once daily, and Nutricomp nutritional support — 400 ml a day orally, selenotherapy is carried out, including the administration of selenium forte 1,000 mcg, once daily, orally for 12 days.

EFFECT: method makes it possible to increase the effectiveness of treatment by replenishing selenium deficiency in patients with septic encephalopathy and improve the overall outcome of 28-day mortality.

1 cl, 1 ex