METHOD OF POSTOPERATIVE DELIRIUM TREATMENT Russian patent published in 2019 - IPC A61K31/4164 A61P25/00 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to a method of treating postoperative delirium including intravenous dexmedetomidine in the early postoperative period under control of sedation. That is ensured by immediate initiation of an intensive therapy following diagnosing postoperative delirium in two-step combined monitoring of sedation and delirium, wherein at the first step, assessing agitation – sedation with the help of a Richmond score (RASS) score and in the case of an estimate of -3 to +5 points, a transition to a second step is performed – delta estimation based on a CAM-ICU scale, then dexmedetomidine is introduced in microfluid for 24 hours in dose of 0.8 mcg/kg/h, thereafter, the patient is brought into a diagnostic window, wherein in case of acute change of mental status or fluctuation thereof combined with inattentiveness or disorganized thinking, or a violation of the level of consciousness, the dexmedetomidine is administered again for 24 hours in dose of 0.8 mcg/kg/h, then the dexmedetomidine infusion is deactivated with the following assessment of the patient's mental status on the CAM-ICU scale, wherein the length of treatment is determined based on the achieved results of the absence of the signs of acute disturbances of mental status in the patient in accordance with the above diagnostic algorithm, but not more than 8 days.

EFFECT: invention allows to reduce intensity of clinical manifestations of delirium and to reduce duration of development of delirium in postoperative patients, to increase diagnostic and therapeutic possibilities, to provide wide application of a method of delirium treatment irrespective of type of operation.

1 cl, 2 ex