FIELD: pharmaceutical industry.
SUBSTANCE: invention relates to derivatives of 4-aminoquinazolines containing an N-hydroxycarboxamide fragment attached to 4-aminoquinazoline through a methylenecyclohexyl fragment. The compounds of the invention are hydroxamic acids derived from 4-aminoquinazoline of general formula (I), where R is either hydrogen or halogen.
EFFECT: compounds according to the invention selectively inhibit isoform 6 histone deanetylase in comparison with histone deacetylase 1, and also possess anti-angiogenic properties.
3 cl, 2 tbl, 11 ex
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