QUINAZOLINE DERIVATIVES INDUCING FERROPTOSIS IN METASTATIC MELANOMA CELLS AND COLON CANCER Russian patent published in 2020 - IPC C07D403/04 A61K31/517 A61P35/00 

Abstract RU 2722308 C1

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry and specifically to a heterocyclic compound of the formula given below, where R1 is hydrogen or halogen; R2, R3, R4 are hydrogen or halogen, with the exception of benzyl 2-((2-(3,5-dimethyl-1H-pyrazol-1-yl)-4-oxoquinazoline-3(4H)-yl)oxy)acetate, capable of inducing ferroptosis in metastatic melanoma and colon cancer cells.

EFFECT: technical result is obtaining novel quinazoline derivatives having useful biological properties.

1 cl, 2 dwg

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RU 2 722 308 C1

Authors

Vartanyan Amaliya Artashevna

Osipov Vasilij Nikolaevich

Khochenkov Dmitrij Aleksandrovich

Gusev Dmitrij Vasilevich

Borisova Larisa Mikhajlovna

Dates

2020-05-28Published

2019-07-04Filed