FIELD: chemistry.
SUBSTANCE: invention relates to 4-((aryl)(methyl)amino)quinazoline-7-carboxylic acid derivatives having the following general formula:
,
where R1 is hydrogen or methyl, R2 is hydrogen or OMe, A is -(CH2)5- or para-phenylene (-C4H6-), as well as methods of their production.
EFFECT: novel compounds are obtained, which have inhibitory activity on histone deacetylase (HDAC) and can be used in medicine for treating oncological diseases.
3 cl, 1 tbl, 1 dwg, 20 ex
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