FIELD: biotechnology.
SUBSTANCE: group of inventions including a chimeric antisense oligonucleotide for the treatment or prevention of hepatitis B virus (HBV), a pharmaceutical composition for the treatment of hepatitis, a method of treating a subject with HBV, a method of inhibiting HBV gene expression in a cell, a method of lowering the level of HBV antigen in a subject infected with HBV are described. In one embodiment, the chimeric antisense oligonucleotide is represented by the following formula (VI): 5` X-Y-Z 3` (VI), where X-Y-Z is a chimeric oligonucleotide and the total length with X-Y-E is 18 to 22 nucleosides.
EFFECT: invention expands the arsenal of agents for the treatment or prevention of hepatitis B virus (HBV).
19 cl, 27 dwg, 52 tbl, 5 ex
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