FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, specifically, to oligonucleotides for reducing the levels of tau mRNA, and can be used in medicine for treating tau-associated diseases. Proposed are oligonucleotides with the sequence G*T*mC*T*G*mCmCTGTGGmCTmCmC*A*mC*G*A* (SEQ ID NO: 329) or A*G*T*mC*A*mCTmCTGGTGAAT*mC*mC*A*A* (SEQ ID NO: 405), wherein nucleotides with * have a 2’-O-MOE-modification, nucleotides without * constitute 2’-deoxynucleosides, and mC stands for 5-methylcytosine.
EFFECT: production of modified antisense oligonucleotides inhibiting the mRNA of MART and thereby reducing the level of tau.
4 cl, 5 dwg, 17 tbl, 12 ex
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