STRAINS OF STAPHYLOCOCCUS AUREUS (MSSA) CHARACTERIZED BY MEC-INDEPENDENT MECHANISMS OF RESISTANCE TO BETA-LACTAMS AND USED AS CONTROL TEST CULTURES TO DETERMINE THE SENSITIVITY TO BETA-LACTAM ANTIBIOTICS Russian patent published in 2023 - IPC C12N1/20 C12R1/445 

FIELD: microbiology.

SUBSTANCE: following is proposed: a strain of Staphylococcus aureus OXA 45 which is characterized by a mec-independent mechanism of resistance to beta-lactam antibiotics and contains mutations in the pbp4 promoter region. This strain has been deposited with the State Collection of Pathogenic Microorganisms and Cell Cultures (GKPM-Obolensk) under registration number B-9986. A strain of Staphylococcus aureus OXA 68 is also proposed, which is characterized by a mec-independent mechanism of resistance to beta-lactam antibiotics and contains mutations in pbp1, pbp2, gdpP. The strains were deposited with the State Collection of Pathogenic Microorganisms and Cell Cultures (GKPM-Obolensk) under the following registration number: В-9987.

EFFECT: strains can be used as a control test culture to determine sensitivity to beta-lactam antibiotics.

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