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2 802 995

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IPC

A61N1/36(2006-01-01)

A61N5/67(2006-01-01)

A61N7/02(2006-01-01)

C12N15/86(2006-01-01)

G09B23/28(2006-01-01)

(21) (22)

Application

2022114467, 2022-05-30

(24)

Start date

2022-05-30

(22)

Actual filing date

2022-05-30

(45)

Published

2023-09-05

(72)

Inventor

Belousov Vsevolod VadimovichNesterenko Aleksej MikhajlovichBalatskij Aleksandr VladimirovichLanin Aleksandr AleksandrovichFedotov Andrej BorisovichMozhaev Andrej Aleksandrovich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Nauki Institut Bioorganicheskoj Khimii Imeni Akademikov M.M. Shemyakina I Yu.A. Ovchinnikova Rossijskoj Akademii Nauk Ran)

METHOD OF CONTROL OF HEART RHYTHM AND REDUCTION OF INDIVIDUAL CARDIOMYOCYTES USING THERMOGENETICS Russian patent published in 2023 - IPC A61N1/36 A61N5/67 A61N7/02 C12N15/86 G09B23/28

Abstract RU 2802995 C1

FIELD: medicine; biotechnology.

SUBSTANCE: invention can be used to control the contraction of cardiomyocytes using thermogenetics. A genetic construct containing a cardiospecific promoter and a human thermally activated TRPV1 channel gene is delivered to cardiomyocytes, followed by heating with laser or ultrasonic radiation pulses with a frequency of 2 to 7 Hz.

EFFECT: method provides the possibility of non-invasive control of the heart rhythm and contractions of individual cardiomyocytes by imposing a rhythm with a frequency of 2 to 7 Hz.

6 cl, 4 dwg, 2 ex

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RU 2 802 995 C1

Authors

Belousov Vsevolod Vadimovich

Nesterenko Aleksej Mikhajlovich

Balatskij Aleksandr Vladimirovich

Lanin Aleksandr Aleksandrovich

Fedotov Andrej Borisovich

Mozhaev Andrej Aleksandrovich

Dates

2023-09-05—Published

2022-05-30—Filed