FIELD: biotechnology.
SUBSTANCE: invention relates to the use of the thiamine pyrophosphate kinase (TPK) gene or protein as a target for the treatment, prevention of Alzheimer's disease, in the screening of a medicinal product for the prevention or treatment of Alzheimer's disease, as a target for the production of a medicinal product for the prevention or treatment of the disease Alzheimer's, as well as in the construction of animal models of Alzheimer's disease. Also the following is disclosed: the use of a reagent that stimulates TPK protein kinase activity in the brain and/or the level of TPK protein expression in the brain in the preparation of a medicinal product for the treatment or prevention of Alzheimer's disease. The invention also relates to a medicinal product that contains the TKR gene or the TKR protein.
EFFECT: invention is effective for preventing or treating Alzheimer's disease.
25 cl, 13 dwg, 3 ex
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