FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, in particular to a genetically modified LEPR gene knockout rabbit. Said rabbit is designed to create a model of morbid obesity and lipid and carbohydrate metabolism disorders and carries a deletion in the rabbit LEPR gene, including part of exon 10, intron 10 and part of exon 11. Present invention also relates to a method of producing said genetically modified rabbit using a CRISPR/Cas9 system.
EFFECT: present invention provides genetic modification (deletion) in the rabbit genome in the LEPRgene locus.
2 cl, 6 dwg, 7 ex
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