FIELD: biotechnology.
SUBSTANCE: group of inventions is described, including a gene transcription repressor of microtube associated protein tau (hereinafter – MAPT), polynucleotide encoding a transcription repressor, a gene delivery agent, a pharmaceutical composition for suppression of MAPT expression, the use of a transcription repressor, polynucleotide, a gene delivery agent, and/or a pharmaceutical composition for suppression of MAPT expression in a subject, and a kit for suppression of MAPT expression.
EFFECT: invention expands the arsenal of agents for suppression of MAPT expression.
30 cl, 17 dwg, 3 tbl, 11 ex
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