PYRIDYLPYRIDONES Russian patent published in 2023 - IPC C07D213/69 C07D213/73 C07D213/75 C07D241/04 C07D401/04 C07D401/14 C07D409/14 C07D413/04 C07D413/14 A61K31/44 A61K31/4412 A61K31/444 A61K31/4545 A61K31/495 A61K31/5377 A61P35/00 A61P3/10 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, where X represents C=O or a bond; R¹ is selected from the group consisting of H, C₁-C₃alkyl, C₁-C₃alkoxyC₁-C₃alkyl, C₃-C₆cycloalkyl, C₁-C₃alkoxy, N,N-diC₁-C₃alkylamino and 1-pyrrolidinyl, with the proviso that when R¹ is C₁-C₃alkoxy, N,N-diC₁-C₃alkylamino or 1-pyrrolidinyl, X is C=O; R² represents a hydrogen atom; R³ is selected from the group consisting of A, phenyl and monocyclic heteroaryl, the said monocyclic heteroaryl is selected from the group consisting of pyridine, thiophene and pyrazole, and the said phenyl and the said heteroaryl are optionally substituted with one or two of R⁴, R⁵, R⁶ and R⁷; R⁴, R⁵, R⁶ and R⁷ are independently selected from the group consisting of halogen, C₁-C₆alkyl, C₁-C₃haloalkoxy and C₁-C₆haloalkyl; A represents R¹² is selected from the group consisting of C₁-C₃alkoxyC₁-C₃alkyl, C₃-C₆cycloalkyl and C₁-C₃haloalkyl; Y is selected from the group consisting of CH₂, NSO₂R⁹, O and a bond. The invention also relates to a pharmaceutical composition for the inhibition of Vps34 based on these compounds.

EFFECT: obtaining new compounds and a pharmaceutical composition based on them which can be used in medicine in the treatment of cancer.

25 cl, 2 tbl, 72 ex