METHOD FOR OBTAINING ANTIMICROBIAL PEPTIDOMIMETIC Russian patent published in 2023 - IPC C07K1/10 C07K5/09 A61K38/06 A61P31/00 

FIELD: pharmaceutical industry.

SUBSTANCE: invention relates to a method for producing an antimicrobial peptidomimetic tripeptide of the formula H-Arg-Tbt-Arg-NH-C₂H₄-Ph by peptide synthesis in solution. The claimed method is characterized in that it includes the step of producing tert-butoxycarbonyl-L-arginine phenethylamide by the carbodiimide method, followed by deprotection of the tert-butoxycarbonyl group and obtaining phenethylamide-L-arginine dihydrochloride, obtaining a protected dipeptide - tert-butoxycarbonyl-2,5, 7-tri(tert-butyl)-tryptophanyl-arginine (2-phenylethyl)amide by the carbodiimide method, followed by removal of the tert-butoxycarbonyl group and obtaining dihydrochloride 2,5,7-tri(tert-butyl)-tryptophanyl-arginine (2-phenylethyl )amide, and obtaining a protected tripeptide - tert-butoxycarbonyl-L-arginyl-2,5,7-tri(tert-butyl)-tryptophanyl-arginine(2-phenylethyl)amide, followed by removal of the tert-butoxycarbonyl group, whereas at the stage of obtaining a protected dipeptide, an excess of 20 mole percent of phenethylamide-L-arginine dihydrochloride is used, and at the stage of obtaining a protected tripeptide, an excess of 20 mole percent of tert-butoxycarbonyl-L-arginine is used.

EFFECT: improved performance of tripeptide.

1 cl, 1 dwg, 1 ex