PORCINE REPRODUCTIVE RESPIRATORY SYNDROME VACCINE VIRUS Russian patent published in 2023 - IPC C12N7/02 A61K39/12 A61P31/14 

FIELD: biotechnology; virology; veterinary.

SUBSTANCE: modified live porcine reproductive and respiratory syndrome (PRRS) virus is presented. The consensus complementary DNA sequence of this PRRS strain is at least 95% identical to a sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3 and SEQ ID NO: 4. An immunogenic composition containing a modified live strain of the PRRS virus, and a vaccine for the treatment or prevention of symptoms of porcine reproductive and respiratory syndrome in a pig, containing a modified live strain of the PRRS virus is presented. The specified PRRS virus strain is DE 14-3073 strain, designated PTA-125490; ES 13-49 strain, designated PTA-125489; IT 14-32 strain, designated PTA-125488, or PL 14-02 strain, designated PTA-125487. The use of a vaccine containing a modified live strain of the PRRS virus is proposed for the treatment or prevention of symptoms of porcine reproductive and respiratory syndrome in pigs. The claimed invention provides protection against the heterologous virulent IT 14-25 strain.

EFFECT: claimed strain has significant effectiveness as an immunogenic composition, since it induces protective immunity against a heterologous PRRSV strain of type 1 when administered as a vaccine.

9 cl, 1 dwg, 3 ex