FIELD: organic chemistry; pharmacology.
SUBSTANCE: use of 4'-hydroxy-1'-(2-hydroxyphenyl)-3'-acyl-spiro[benzo[b][1,4]thiazine-2,2'-pyrrole] -3,5'(1'H, 4H)-diones of the general formula:
where R = 2-furyl (a), 4-C6H4NO2 (b) as an anti-tuberculosis agent. The above compounds have been shown to have anti-tuberculosis activity.
EFFECT: development of a drug with anti-tuberculosis activity, which can be used in pharmacology as a potential drug with anti-tuberculosis properties.
1 cl, 1 tbl, 3 ex
| Title |
Year |
Author |
Number |
| 4'-HYDROXY-1'-(2-HYDROXYPHENYL)-3'-(4-R-BENZOYL)SPIRO[BENZO[B][1,4]THIAZINE-2,2'-PYRROLE]-3,5'( 1'H,4H)-DIONE |
2022 |
- Mashevskaia Irina Vladimirovna
- Lukmanova Dzhamilia Nailevna
- Dmitriev Maksim Viktorovich
- Balandina Svetlana Iurevna
|
RU2783263C1 |
| ANTITUBERCULOSIS AGENT BASED ON (Z)-9-AROYL-8-HYDROXY-6-(2-HYDROXYPHENYL)-2-(((E)-PYRIDIN-3-YLMETHYLENE)HYDRAZONO)-1-THIA-3,6-DIAZOSPIRO[4.4]NON-8-ENE-4,7-DIONES |
2023 |
- Lukmanova Dzhamilia Nailevna
- Mashevskaia Irina Vladimirovna
- Balandina Svetlana Iurevna
|
RU2808987C1 |
| APPLICATION OF 3'-AROYL-4'-HYDROXY-1'-(2-HYDROXYETHYL)SPIRO[BENZO[b][1,4]THIAZINE-2,2'-PYRROLE]-3,5'(1'H,4 H)-DIONES AS AGENTS WITH ANALGESIC ACTIVITY |
2021 |
- Maslivets Andrej Nikolaevich
- Tretyakov Nikita Alekseevich
- Makhmudov Ramiz Ragibovich
|
RU2775547C1 |
| APPLICATION OF 3'-(4-BROMOBENZOYL)-4'-HYDROXY-1'-(2-HYDROXYETHYL)SPIRO[BENZO[B][1,4]THIAZINE-2,2'-PYRROLE]-3,5'(1 'H,4H)-DIONE AS AGENT WITH ANTIMICROBIAL ACTIVITY AGAINST S. AUREUS CULTURE |
2023 |
- Tretiakov Nikita Alekseevich
- Maslivets Andrei Nikolaevich
- Balandina Svetlana Iurevna
|
RU2806038C1 |
| APPLICATION OF 2-[(R-BENZYLIDENE)HYDRAZONO]-8-HYDROXY-6-(2-HYDROXYPHENYL)-9-AROYL-1-THIA-3,6-DIAZASPIRO[4.4]NONA-8-EN-4,7-DIONES AS AGENTS WITH ANTI-INFLAMMATORY ACTIVITY |
2022 |
- Mashevskaia Irina Vladimirovna
- Lukmanova Dzhamilia Nailevna
- Apushkin Danila Iurevich
- Utushkina Taisiia Andreevna
- Iakushina Karolina Evgenevna
- Andreev Aleksandr Igorevich
|
RU2783241C1 |
| ANTI-TUBERCULOSIS AGENT BASED ON 4-((HET)AROYL)-3-HYDROXY-1-(2-HYDROXYPHENYL)-5-(PHENYLTHIO)-1,5-DIHYDRO-2H-PYRROL-2-ONES |
2021 |
- Mashevskaya Irina Vladimirovna
- Balandina Svetlana Yurevna
- Lukmanova Dzhamilya Nailevna
|
RU2767542C1 |
| ANTIOXIDANT BASED ON 2-[(R-BENZYLIDENE)HYDRAZONO]-8-HYDROXY-6-(2-HYDROXYPHENYL)-9-(4-BROMBENZOYL)-1-THIA-3,6-DIAZASPIRO[4.4]NONA-8-EN-4,7-DIONES |
2023 |
- Lukmanova Dzhamilia Nailevna
- Mashevskaia Irina Vladimirovna
- Dmitriev Maksim Viktorovich
|
RU2806329C1 |
| (E)-N'-((SUBSTITUTED-3',3'-DIMETHYL-3'H-SPIRO[CHROMENE-2,1'-ISOBENZOFURAN]-8-YL)METHYLENE)ISONICOTINOHYDRAZIDES, HAVING ANTI-TUBERCULOSIS ACTIVITY, AND METHOD THEREOF OBTAINING |
2024 |
- Zantman Anastasiia Aleksandrovna
- Bulanov Antonii Olegovich
- Shcherbakov Igor Nikolaevich
|
RU2824628C1 |
| (Z)-9-AROYL-8-HYDROXY-6-(2-HYDROXYPHENYL)-2-(((Z)-2-OXOINDOLIN-3-YLIDENE)HYDRAZONO)-1-THIA-3,6-DIAZASPIRO[4.4 ]NON-8-EN-4,7-DIONES WITH ANTIMICROBIAL ACTIVITY |
2021 |
- Mashevskaya Irina Vladimirovna
- Dmitriev Maksim Viktorovich
- Balandina Svetlana Yurevna
- Lukmanova Dzhamilya Nailevna
|
RU2763739C1 |
| 3'-AROYL-4'-HYDROXY-1'-(2-HYDROXYMETHYLPHENYL)-2H,4H-SPIRO[1,4-BENZOTHIAZINE-2,2'-PYRROLE]-3,5'(1'H)-DIONES, HAVING ANALGESIC ACTIVITY |
2019 |
- Maslivets Anna Andreevna
- Maslivets Andrej Nikolaevich
- Makhmudov Ramiz Ragibovich
- Tretyakov Nikita Alekseevich
|
RU2714511C1 |
