COMBINATION OF QUINOLINE-4-CARBOXAMIDES AND BENZONAPHTHYRIDINE DERIVATIVES AS A COMBINED ANTIMALARIA MEDICINE Russian patent published in 2023 - IPC A61K31/357 A61K31/4745 A61K31/5377 A61P33/06 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: group of inventions can be used for the treatment and/or prevention of malaria. The following is proposed: a combination for the treatment and/or prevention of malaria including as the first active ingredient (2-pyrrolidin-1-yl-ethyl)-amide 6-fluoro-2-(4-morpholin-4-ylmethyl-phenyl)-quinoline-4-carboxylic acid or a pharmaceutically acceptable salt thereof and either pyronaridine or a pharmaceutically acceptable salt thereof as the second active ingredient. Also the following is proposed: a pharmaceutical composition containing the two indicated active ingredients, a kit for the treatment of malaria and a method of treating and/or preventing malaria in a patient, including administering to the patient a therapeutically active amount of the combination (2-pyrrolidin-1-yl-ethyl)-amide 6-fluoro-2-(4-morpholin-4-ylmethyl-phenyl)-quinoline-4-carboxylic acid and pyronaridine or a pharmaceutically acceptable salt of any of the above components, including mixtures thereof.

EFFECT: group of inventions provides increased effectiveness of treatment and/or prevention of malaria, and also pyronaridine, which is an inhibitor of P-glycoprotein, has a positive effect on the penetration of (2-pyrrolidin-1-yl-ethyl)-amide 6-fluoro-2-(4) through the intestinal wall -morpholin-4-ylmethyl-phenyl)-quinoline-4-carboxylic acid (and any of its salts) in a small dose, thereby positively affecting the therapeutic window.

11 cl, 6 tbl