FIELD: biotechnology.
SUBSTANCE: artificial bsi-cov gene was constructed and encodes an artificial T-cell polyepitope BSI-COV immunogen protein having the following sequence SEQ ID NO: 2. The following was created: pBSI-COV plasmid DNA, having the following nucleotide sequence of SEQ ID NO: 1, 4156 bp in size, molecular weight 2.6 MDa, containing the specified target gene. An artificial polyepitope protein-immunogen BSI-COV has been obtained with the following amino acid sequence of SEQ ID NO: 3 412 a.a. long. The resulting construct induces SARS-CoV-2-specific T-cell immunity.
EFFECT: creation of a vaccine construct in the form of pBSI-COV plasmid DNA, which provides a longer inducing SARS-CoV-2-specific T-cell immune response.
3 cl, 8 dwg, 5 tbl, 5 ex
| Title |
Year |
Author |
Number |
| ARTIFICIAL GENE ENCODING THE BSI-COV-UB IMMUNOGEN PROTEIN, RECOMBINANT PLASMID DNA PBSI-COV-UB, WHICH ENSURES THE EXPRESSION OF THE TARGET GENE, AND AN ARTIFICIAL POLYEPITOPE BSI-COV-UB IMMUNOGEN PROTEIN CONTAINING UBIQUITIN AND EPITOPES OF SARS-CoV-2 VIRUS ANTIGENS AND INDUCING SARS-CoV-2-SPECIFIC T-CELL IMMUNITY |
2023 |
- Bazhan Sergej Ivanovich
- Borgoyakova Mariya Borisovna
- Karpenko Larisa Ivanovna
- Rudometov Andrej Pavlovich
- Starostina Ekaterina Vladimirovna
- Ilichev Aleksandr Alekseevich
|
RU2806590C1 |
| PLASMID DNA MATRIX AND mRNA MOLECULE USED TO PRODUCE VACCINE AGAINST CORONAVIRUS, OBTAINED USING DNA MATRIX AND PROVIDING EXPRESSION OF GENE OF ARTIFICIAL POLYEPITOPIC PROTEIN-IMMUNOGEN CONTAINING CONSERVED EPITOPES OF SARS-CoV-2 VIRUS ANTIGENS AND INDUCING SARS-CoV-2-SPECIFIC IMMUNITY |
2024 |
- Borgoyakova Mariya Borisovna
- Rudometov Andrej Pavlovich
- Karpenko Larisa Ivanovna
- Ilichev Aleksandr Alekseevich
- Starostina Ekaterina Vladimirovna
- Tigeeva Elena Vitalevna
- Sharabrin Sergej Valerevich
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- Kisakova Lyubov Aleksandrovna
|
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2017 |
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- Karpenko Larisa Ivanovna
- Oreshkova Svetlana Fedorovna
- Smirnova Olga Yurevna
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|
RU2650872C1 |
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2012 |
- Antonets Denis Viktorovich
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- Il'Ichev Aleksandr Alekseevich
- Karpenko Larisa Ivanovna
- Borobova Elena Aleksandrovna
- Starostina Ekaterina Vladimirovna
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|
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2002 |
- Bazhan S.I.
- Belavin P.A.
- Seregin S.V.
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- Daniljuk N.K.
- Sandakhchiev L.S.
|
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2022 |
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- Karpenko Larisa Ivanovna
- Shcherbakov Dmitrij Nikolaevich
- Rudometov Andrej Pavlovich
- Starorstina Ekaterina Vladimirovna
- Merkuleva Yuliya Aleksandrovna
- Shanshin Daniil Vasilevich
- Isaeva Anastasiya Aleksandrovna
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|
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2021 |
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|
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2020 |
- Imatdinov Ilnaz Ramisovich
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2024 |
- Sharabrin Sergej Valerevich
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- Kisakova Lyubov Aleksandrovna
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2020 |
- Imatdinov Ilnaz Ramisovich
- Bochkareva Mariya Dmitrievna
- Prudnikova Elena Yurevna
- Tishin Anton Evgenevich
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|
RU2733832C1 |
