FIELD: biotechnology.
SUBSTANCE: artificial bsi-cov gene was constructed and encodes an artificial T-cell polyepitope BSI-COV immunogen protein having the following sequence SEQ ID NO: 2. The following was created: pBSI-COV plasmid DNA, having the following nucleotide sequence of SEQ ID NO: 1, 4156 bp in size, molecular weight 2.6 MDa, containing the specified target gene. An artificial polyepitope protein-immunogen BSI-COV has been obtained with the following amino acid sequence of SEQ ID NO: 3 412 a.a. long. The resulting construct induces SARS-CoV-2-specific T-cell immunity.
EFFECT: creation of a vaccine construct in the form of pBSI-COV plasmid DNA, which provides a longer inducing SARS-CoV-2-specific T-cell immune response.
3 cl, 8 dwg, 5 tbl, 5 ex
| Title |
Year |
Author |
Number |
| ARTIFICIAL GENE ENCODING THE BSI-COV-UB IMMUNOGEN PROTEIN, RECOMBINANT PLASMID DNA PBSI-COV-UB, WHICH ENSURES THE EXPRESSION OF THE TARGET GENE, AND AN ARTIFICIAL POLYEPITOPE BSI-COV-UB IMMUNOGEN PROTEIN CONTAINING UBIQUITIN AND EPITOPES OF SARS-CoV-2 VIRUS ANTIGENS AND INDUCING SARS-CoV-2-SPECIFIC T-CELL IMMUNITY |
2023 |
- Bazhan Sergej Ivanovich
- Borgoyakova Mariya Borisovna
- Karpenko Larisa Ivanovna
- Rudometov Andrej Pavlovich
- Starostina Ekaterina Vladimirovna
- Ilichev Aleksandr Alekseevich
|
RU2806590C1 |
| ARTIFICIAL GENE MEL-TCI, CODING POLYEPITOPIC PROTEIN-IMMUNOGENE MEL-TCI, RECOMBINANT PLASMID DNA PMEL-TCI PROVIDING EXPRESSION OF ARTIFICIAL GENE MEL-TCI AND ARTIFICIAL PROTEIN-IMMUNOGENE MEL-TCI, CONTAINING CTL- AND Th-DETERMINANTS OF MELANOMA ANTIGENES RESTRUCTURED BY PLURAL ALLELS HLA OF I AND II CLASS |
2017 |
- Antonets Denis Viktorovich
- Borobova Elena Aleksandrovna
- Ilichev Aleksandr Alekseevich
- Karpenko Larisa Ivanovna
- Oreshkova Svetlana Fedorovna
- Smirnova Olga Yurevna
- Starostina Ekaterina Vladimirovna
- Bazhan Sergej Ivanovich
|
RU2650872C1 |
| MEL-TCI-A0201 ARTIFICIAL GENE CODING MEL-TCI-A0201 POLYEPITOPE IMMUNOGENIC PROTEIN, RECOMBINANT PLASMID DNA OF pMEL-TCI-A0201, PROVIDING EXPRESSION OF MEL-TCI-A0201 ARTIFICIAL GENE AND MEL-TCI-A0201 ARTIFICIAL IMMUNOGENIC PROTEIN CONTAINING MULTIPLE CTL- AND Th-EPITOPES OF MELANOMA ANTIGENS |
2012 |
- Antonets Denis Viktorovich
- Bazhan Sergej Ivanovich
- Il'Ichev Aleksandr Alekseevich
- Karpenko Larisa Ivanovna
- Borobova Elena Aleksandrovna
- Starostina Ekaterina Vladimirovna
- Smirnova Ol'Ga Jur'Evna
- Oreshkova Svetlana Fedorovna
|
RU2522830C2 |
| ARTIFICIAL PROTEIN-IMMUNOGEN TCI COMPRISING MULTIPLE CTL-EPITOPES OF HIV-1 BASIC ANTIGENS, ARTIFICIAL GENE TCI ENCODING POLYEPITOPE PROTEIN-IMMUNOGEN TCI |
2002 |
- Bazhan S.I.
- Belavin P.A.
- Seregin S.V.
- Babkina I.N.
- Daniljuk N.K.
- Sandakhchiev L.S.
|
RU2238946C2 |
| CONJUGATE OF THE RECEPTOR-BINDING DOMAIN (RBD) PROTEIN OF SARS-CoV-2 SURFACE GLYCOPROTEIN S WITH POLYGLUCIN-SPERMIDINE (PGS) POLYMER AND VACCINE COMPLEX AGAINST CORONAVIRUS INFECTION COVID-19 BASED ON THE SPECIFIED CONJUGATE AND PLASMID DNA PVAX-RBD |
2022 |
- Borgoyakova Marina Borisovna
- Karpenko Larisa Ivanovna
- Shcherbakov Dmitrij Nikolaevich
- Rudometov Andrej Pavlovich
- Starorstina Ekaterina Vladimirovna
- Merkuleva Yuliya Aleksandrovna
- Shanshin Daniil Vasilevich
- Isaeva Anastasiya Aleksandrovna
- Nesmeyanova Valentina Sergeevna
- Volkova Natalya Vyacheslavovna
- Belenkaya Svetlana Valerevna
- Volosnikova Ekaterina Aleksandrovna
- Zadorozhnyj Aleksej Mikhajlovich
- Zajtsev Boris Nikolaevich
- Orlova Lyubov Aleksandrovna
- Zajkovskaya Anna Vladimirovna
- Pyankov Oleg Viktorovich
- Ilichev Aleksandr Alekseevich
|
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| ARTIFICIAL GENE N1NEW, ENCODING NUCLEOCAPSID PROTEIN OF CORONAVIRUS SARS-CoV-2, AND RECOMBINANT PLASMID PET-28A-N1NEW, PROVIDING EXPRESSION OF THE ARTIFICIAL GENE |
2021 |
- Belozerova Natalya Sergeevna
- Pletyukhina Yuliya Vladimirovna
- Rabdano Sevastyan Olegovich
- Savelev Nikita Sergeevich
- Fakhretdinova Liliya Niyazovna
- Trukhin Viktor Pavlovich
- Evtushenko Anatolij Eduardovich
- Musa Rakhimovich Khaitov
- Skvortsova Veronika Igorevna
|
RU2762962C1 |
| ARTIFICIAL GENE CODING A BICISTRONIC STRUCTURE FORMED BY RECEPTOR-BINDING DOMAIN SEQUENCES OF THE GLYCOPROTEIN S OF THE SARS-COV-2 CORONAVIRUS, P2A-PEPTIDE AND GLYCOPROTEIN G VSV, RECOMBINANT PLASMID PSTEM-RVSV-STBL_RBD_SC2, PROVIDING EXPRESSION OF ARTIFICIAL GENE, AND A RECOMBINANT STRAIN OF VESICULAR STOMATITIS VIRUS RVSV-STBL_RBD_SC2, USED TO CREATE A VACCINE AGAINST SARS-COV-2 CORONAVIRUS |
2020 |
- Imatdinov Ilnaz Ramisovich
- Bochkareva Mariya Dmitrievna
- Prudnikova Elena Yurevna
- Tishin Anton Evgenevich
- Pyankov Oleg Viktorovich
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- Maksyutov Rinat Amirovich
|
RU2733831C1 |
| ARTIFICIAL GENE STBL_RBD_TRM_SC2, CODING A BICISTRONIC STRUCTURE FORMED BY THE SARS-COV-2 CORONAVIRUS GLYCOPROTEIN S RECEPTOR-BINDING DOMAIN SEQUENCES, TRANSMEMBRANE REGION, P2A-PEPTIDE AND GLYCOPROTEIN G VSV, RECOMBINANT PLASMID PSTEM-RVSV-STBL_RBD_TRM_SC2, PROVIDING EXPRESSION OF ARTIFICIAL GENE, AND A RECOMBINANT STRAIN OF VESICULAR STOMATITIS VIRUS RVSV-STBL_RBD_TRM_SC2, USED TO CREATE A VACCINE AGAINST SARS-COV-2 CORONAVIRUS |
2020 |
- Imatdinov Ilnaz Ramisovich
- Bochkareva Mariya Dmitrievna
- Prudnikova Elena Yurevna
- Tishin Anton Evgenevich
- Pyankov Oleg Viktorovich
- Gavrilova Elena Vasilevna
- Maksyutov Rinat Amirovich
|
RU2733832C1 |
| ARTIFICIAL ECTOS_SC2 GENE ENCODING AN ECTODOMAIN OF THE SARS-COV-2 CORONAVIRUS S GLYCOPROTEIN WITH A C-TERMINAL TRIMERIZATION DOMAIN, A RECOMBINANT PLASMID PSTEM-RVSV-ECTOS_SC2, WHICH PROVIDES EXPRESSION OF THE ARTIFICIAL GENE, AND A RECOMBINANT STRAIN OF VESICULAR STOMATITIS VIRUS RVSV-ECTOS_SC2, USED TO CREATE A VACCINE AGAINST SARS-COV-2 CORONAVIRUS |
2020 |
- Imatdinov Ilnaz Ramisovich
- Bochkareva Mariya Dmitrievna
- Prudnikova Elena Yurevna
- Tishin Anton Evgenevich
- Pyankov Oleg Viktorovich
- Gavrilova Elena Vasilevna
- Maksyutov Rinat Amirovich
|
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| ARTIFICIAL GENES CODING EV.CTL AND EV.Th PROTEINS-IMMUNOGENS, RECOMBINANT PLASMID DNA pEV.CTL AND EV.Th, PROVIDING EXPRESSION OF ARTIFICIAL GENES, AND ARTIFICIAL T-CELL POLYEPITOPE PROTEINS-IMMUNOGENS EV.CTL AND EV.Th CONTAINING EPITOPES OF EBOLA VIRUS ANTIGENS, USED TO CREATE AN EBOLA VIRUS VACCINE |
2018 |
- Antonets Denis Viktorovich
- Bazhan Sergej Ivanovich
- Ilichev Aleksandr Alekseevich
- Kaplina Olga Nikolaevna
- Karpenko Larisa Ivanovna
- Smirnova Olga Yurevna
- Oreshkova Svetlana Fedorovna
|
RU2713723C1 |
