BINDING DOMAINS OF ANTI-CD3 ANTIBODIES AND ANTIBODIES CONTAINING THEM, AS WELL AS METHODS OF THEIR PREPARATION AND APPLICATION Russian patent published in 2023 - IPC C07K16/28 C07K16/30 C07K16/32 A61K39/395 

FIELD: biotechnology.

SUBSTANCE: invention is related to an antibody or an antigen-binding fragment of an antibody that specifically binds to CD3. A polypeptide that specifically binds to CD3, an antibody containing an antibody or an antigen binding fragment of an antibody, a nucleic acid encoding an antibody or an antigen binding fragment of an antibody or the specified polypeptide, an expression vector containing the specified nucleic acid, a host cell containing the specified nucleic acid or vector, as well as a composition for use in the treatment of a disease associated with CD3, containing the specified antibody or antigen-binding fragment of an antibody or polypeptide, are also disclosed.

EFFECT: invention is effective for activating T cells, as well as treating diseases associated with CD3.

33 cl, 38 dwg, 2 tbl, 2 ex