STRAIN OF ESCHERICHIA COLI BACTERIA WITH REDUCED ABILITY TO ACCUMULATE ACETATE - PRODUCER OF HYBRID POLYPEPTIDE CONTAINING PROINSULIN GLARGINE Russian patent published in 2023 - IPC C12N1/21 C07K14/62 C07K19/00 A61K38/28 A61P3/10 

Abstract RU 2807548 C1

FIELD: biotechnology.

SUBSTANCE: invention relates to the field of biotechnology, namely to the proinsulin-producing strain of insulin glargine Escherichia coli BL21-74/pF644 with a low acetate content during cultivation.

EFFECT: proposed strain can be used to obtain pharmaceutical compositions and finished medicines with an increased content of the active substance.

4 cl,1 dwg, 4 ex

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RU 2 807 548 C1

Authors

Rodionov Petr Petrovich

Latypov Vitalii Feliksovich

Selivanova Tatiana Aleksandrovna

Dates

2023-11-16Published

2023-09-26Filed