NEW SULPHONAMIDE DERIVATIVES WITH SELECTIVE NOX INHIBITORY ACTIVITY Russian patent published in 2023 - IPC C07C311/16 C07D213/34 C07D307/82 A61K31/18 A61K31/343 A61K31/4406 A61P3/00 A61P9/00 A61P11/00 A61P19/08 A61P25/28 A61P29/00 A61P35/00 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula (Ia) or a pharmaceutically acceptable salt thereof that can inhibit nicotinamide adenine dinucleotide phosphate oxidase 4 (Nox4). In formula (Ia) m is equal either to 0 or 1; n is an integer from 2 to 5; each R₁ is independently selected from C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkoxy, hydroxy and halogen; or two R₁ attached to adjacent phenyl ring atoms, together with the phenyl ring atoms to which they are attached, can form a 4–6-membered non-aromatic ring, optionally containing one oxygen atom and optionally substituted by one or more groups independently selected from C1-C3 alkyl and halogen; each R_1a is independently selected from C1-C6 alkyl, hydroxy and halogen; R₂ is selected from C1-C6 alkyl, halogen and hydroxy; R₃, R₄, R₅ and R₆ are independently selected from H and F; any alkyl is optionally substituted with one or more halogens; provided that the compound is not N-[2-(2-hydroxyphenyl)ethyl]-2,4,6-trimethylbenzene-1-sulfonamide, N-[2-(2-hydroxyphenyl)ethyl]-4-methoxy- 2,6-dimethylbenzenesulfonamide, 2,6-dichloro-N-[2-(2-fluorophenyl)ethyl]benzene-1-sulfonamide, 2,4,6-trimethyl-N-[2-(2-methylphenyl)ethyl] benzene-1-sulfonamide, N-[2-(2-fluorophenyl)ethyl]-2,4,6-trimethylbenzene-1-sulfonamide, N-[2-(2-hydroxyphenyl)ethyl]-2-methylbenzene-1- sulfonamide, 2,4-dichloro-N-[2-(2-fluorophenyl)ethyl]benzene-1-sulfonamide, 2-bromo-N-[2-(2-fluorophenyl)ethyl]benzene-1-sulfonamide, 2- chloro-N-[2-(2-fluorophenyl)ethyl]-6-methylbenzene-1-sulfonamide, N-[2-(2-fluorophenyl)ethyl]-2,5-dimethylbenzene-1-sulfonamide or N-[2 -(2-fluorophenyl)ethyl]-2,3,5,6-tetramethylbenzene-1-sulfonamide.

EFFECT: pharmaceutical composition comprising the said compound, its use in the manufacture of a medicinal product for treating a disease that benefits from inhibition of Nox4 activity, and a method for treating a disease that benefits from inhibition of Nox4 activity.

18 cl, 19 dwg, 7 tbl, 48 ex