C17-, C20- AND C21-SUBSTITUTED NEUROACTIVE STEROIDS AND METHODS OF THEIR USE Russian patent published in 2024 - IPC C07J1/00 C07J7/00 C07J9/00 C07J17/00 C07J41/00 C07J43/00 A61K31/565 A61K31/567 A61K31/57 A61K31/573 A61K31/575 A61K31/58 A61P23/00 A61P25/00 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula (1-A) or a pharmaceutically acceptable salt thereof, where: a) a compound of formula (1-A) is a compound of formula (1-A-1), where each R^Y4 is independently C₁-C₂₀ alkyl, cyano or halo; and e is either 0 or 2; or b) a compound of formula (1-A) is a compound of formula (1-A-3) wherein each R^Y1 is hydrogen, C₁-C₆ alkyl, or C₆ cycloalkyl; and each R^Y2 is independently C₁-C₆ alkyl, C₆ cycloalkyl, C₆ heterocyclyl having 1–4 heteroatoms, where each heteroatom is selected from N, O or S, C₆ aryl or C₆ heteroaryl having 1–4 heteroatoms, where each heteroatom is selected from N, O or S; and b= 0 or 1; or c) a compound of formula (1-A) is a compound of formula (1-A-5) wherein each R^Y3 is C₆ aryl or C₅-C₆ heteroaryl having 1–4 heteroatoms, where each heteroatom is selected from N, O or S; or two R^Y3 groups are joined together to form a 6-membered ring; c is 1, 2 or 3; and d is either 0, 1, or 2; and where R³ represents C₁-C₆ alkyl; R^X is independently either hydrogen or C₁-C₆ alkyl, R^Y is independently C₆ aryl, C₆ cycloalkyl, or C₆ heterocyclyl containing 1–4 heteroatoms, where each heteroatom is selected from N, O, or S; or R^X and R^Y are joined together to form a 6-membered heterocyclic ring; R¹⁹ is hydrogen or C₁-C₆ alkyl; R ⁵ is hydrogen; and represents a single bond. The invention also relates to a pharmaceutical composition with the ability to inhibit the function of the GABA receptor, based on these compounds.

EFFECT: obtaining new compounds and a pharmaceutical composition based on them which can be used in medicine in the treatment of cancer.

15 cl, 2 tbl, 108 ex