THRβ RECEPTOR AGONIST AND METHOD OF ITS OBTAINING AND USE Russian patent published in 2023 - IPC C07D403/12 A61K31/53 A61P1/16 A61P3/00 A61P3/04 A61P3/06 A61P3/10 A61P5/14 A61P9/10 A61P35/00 

Abstract RU 2809040 C2

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, which may be useful as a THR receptor agonistβ. In formula (I), R1 is selected from the group consisting of hydrogen, cyano and C1-6 alkyl; R2 and R3 are each an independently selected halogen; ring A is a substituted or unsubstituted C5-10 aromatic ring, where the substituent is selected from the group consisting of hydrogen, halogen and C1-6 alkyl; and the halogen is selected from the group consisting of F, Cl and Br.

EFFECT: invention also relates to a pharmaceutical composition containing the said compound and its use for the manufacture of a therapeutic medicinal product for a thyroid hormone receptor beta-related metabolic disease.

(I)

21 cl, 3 tbl, 21 ex

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RU 2 809 040 C2

Authors

Yu, Shanghai

Li, Ben

Dates

2023-12-06Published

2019-12-12Filed