FIELD: medicine.
SUBSTANCE: invention concerns compounds of general formula 
(I), where: A represents O, CH2, S, SO or SO2; X and Y are chosen from Br, Cl and -CN3; R1 is chosen from the group consisting of -(CH2)nCOOH, -NHC(=O)COOH, -NHCH2COOH, 
;
Z represents H or -C=H; R2 is lower alkyl; R3 - H or lower alkyl; n means 1, 2 or 3; p means 1 or 2; or to their pharmaceutically acceptable salts or esters. Besides the invention covers a pharmaceutical composition based on said compounds expressing an agonist activity in relation to thyroid hormone receptor.
EFFECT: said compounds and pharmaceutical compositions containing thereof there can be effective for treatment of such diseases as obesity, hyperlipidemia, hypercholesterolemia and diabetes, and the other similar conditions and diseases, and can be used for treatment of the other diseases, such as NASH, atherosclerosis, cardiovascular diseases, hypothyroidism, thyroid cancer and the other similar conditions and diseases.
25 cl, 1 tbl, 27 ex
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