PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF NON-ALCOHOLIC STEATHOEPATITIS Russian patent published in 2023 - IPC A61K31/506 A61K31/192 A61K31/495 A61K31/4985 A61P1/16 

FIELD: medicine.

SUBSTANCE: group of inventions relates to the treatment of non-alcoholic fatty infiltration of the liver. The pharmaceutical composition contains the following components:

, where A is an oxadiazole group, B is a pyrimidine group, substituted with a C1-C6 linear or branched alkyl group, X – F; at least one substance selected from pioglitazone, lobeglitazone, elafibranor, lanifibranor, saroglitazar, sitagliptin, vildagliptin, saxagliptin, linagliptin, hemigliptin, anagliptin, teneligliptin, alogliptin, trelagliptin, omarigliptin, evogliptin, gosogliptin, dut ogliptin, firsocostat, obeticholic acid, tropifexor, 3-(2,6-dichlorophenyl)-4-(3'-carboxy-2-chlorostilben-4-yl)oxymethyl-5-isopropylisoxazole and cenicriviroc. Also the following is disclosed: the use of a pharmaceutical composition for the prevention or treatment of non-alcoholic fatty liver disease and for the preparation of a medicinal product, a method of the prevention or treatment of non-alcoholic fatty liver disease.

EFFECT: group of inventions improves lipid metabolism, reduces fat accumulation in liver tissue and suppresses histological damage.

14 cl, 13 dwg, 3 ex