COMPOUND HAVING AGONISTIC ACTIVITY AGAINST GPR119, METHOD FOR ITS PREPARATION, AND PHARMACEUTICAL COMPOSITION CONTAINING IT AS AN EFFECTIVE COMPONENT Russian patent published in 2018 - IPC C07D413/14 C07D413/04 C07D401/04 C07D417/14 A61K31/42 A61K31/425 A61K31/506 A61P3/10 A61P3/04 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to a novel compound of Formula 1 or a pharmaceutically acceptable salt thereof

,

wherein A is oxadiazole, dihydrooxazole, thiazole or thiadiazole optionally substituted with one or more substituents, selected from the group consisting of hydrogen, halogen, straight-chain or branched C1-C6 alkyl and C1-C6 alcohol, wherein the straight-chain or branched C1-C6 alkyl or C1-C6 alcohol group is optionally substituted with hydrogen, halogen or C1-C6 alkoxy; B is pyridine, pyrimidine, pyrazine or oxadiazole optionally substituted with one or more substituents, selected from the group consisting of hydrogen, halogen, straight-chain or branched C1-C6 alkyl, C1-C6 alcohol, C1-C6 alkoxy and oxadiazole groups, wherein the straight-chain or branched C1-C6 alkyl, C1-C6 alcohol, C1-C6 alkoxy or oxadiazole group is optionally substituted with hydrogen, halogen, C1-C6 alkyl group or C1-C6 alkoxy group; and X is independently F, Cl, Br or I, having agonistic activity against GPR119.

EFFECT: pharmaceutically acceptable salt is provided.

19 cl, 6 ex, 3 tbl