METHOD OF TREATING PATIENTS WITH INFERTILITY CAUSED BY FIBROSCLEROTICA OR HYPOPLASTIC TRANSFORMATION OF TENDOMETRIA WITH HISTORY OF REPEATED IMPLANTATION FAILURES IN ART CYCLES Russian patent published in 2023 - IPC A61M37/00 A61K35/28 A61P15/00 

FIELD: medicine; reproductology; IVF methods.

SUBSTANCE: invention can be used to treat patients with infertility caused by fibrosclerotic or hypoplastic transformation of the endometrium with a history of repeated implantation failures in ART cycles. Against the background of hormonal therapy, on the 5th–6th day of the menstrual cycle, a complex transplantation of a cellular product is performed based on autologous bone marrow mesenchymal stem cells (BMSCs) obtained from an iliac crest biopsy. A 100 ml volume of cell product containing BM MSCs immobilized in a gelatin-based transport solution is administered intravenously over 30–40 minutes at the rate of 1 million cells per kg of the patient’s body weight in 100 ml of solution. After this, intrauterine injection of the cell product of 1 ml volume containing 10 million BM MSCs in a similar solution is performed under ultrasound control by irrigation.

EFFECT: method ensures increased effectiveness of treatment, promotes positive dynamics of endometrial growth and its structure, and improves the results of clinical pregnancy in patients.

1 cl, 2 ex, 5 tbl