FIELD: medicine; reproductology; IVF methods.
SUBSTANCE: invention can be used to treat patients with infertility caused by fibrosclerotic or hypoplastic transformation of the endometrium with a history of repeated implantation failures in ART cycles. Against the background of hormonal therapy, on the 5th–6th day of the menstrual cycle, a complex transplantation of a cellular product is performed based on autologous bone marrow mesenchymal stem cells (BMSCs) obtained from an iliac crest biopsy. A 100 ml volume of cell product containing BM MSCs immobilized in a gelatin-based transport solution is administered intravenously over 30–40 minutes at the rate of 1 million cells per kg of the patient’s body weight in 100 ml of solution. After this, intrauterine injection of the cell product of 1 ml volume containing 10 million BM MSCs in a similar solution is performed under ultrasound control by irrigation.
EFFECT: method ensures increased effectiveness of treatment, promotes positive dynamics of endometrial growth and its structure, and improves the results of clinical pregnancy in patients.
1 cl, 2 ex, 5 tbl
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METHOD FOR INCREASING RECEPTIVITY OF ENDOMETRIUM IN PATIENTS WITH UTERINE INFERTILITY DUE TO ENDOMETRIAL DYSFUNCTION, IN PREPARATION FOR PROCEDURE OF IN VITRO FERTILIZATION (IVF) BY CRYOPROTOCOL | 2021 |
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Authors
Dates
2023-12-14—Published
2022-11-24—Filed