METHOD OF INCREASING ENDOMETRIAL THICKNESS FOR INCREASING REPRODUCTIVE OUTCOMES IN PATIENTS WITH "THIN" HYPOPLASTIC ENDOMETRIUM Russian patent published in 2025 - IPC A61K38/19 A61K38/58 A61K38/22 A61P15/08 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to obstetrics and gynaecology, can be used in programs of assisted reproductive technologies (ART) in patients with "thin" hypoplastic endometrium for increasing thickness of endometrium. At the stage of endometrial preparation for embryo implantation with underlying hormonal replacement therapy, estradiol valerate 2 mg is used once day from 5th to 25th day or estradiol in the form of hemihydrate – transdermal gel in dose of 1.5 mg twice a day. In the luteal phase from 16th to 25th day, micronized progesterone is administered orally 100 mg 2 times a day or progesterone in the form of vaginal gel 90 mg 1 time a day or dydrogesterone 10-20 mg 1 time day for 2 to 4 months. Also, the preparation "Superlimph" 25 units is used, one suppository vaginally at night for 20 days from 5th to 25th day of the menstrual cycle for 2 to 4 months to achieve endometrial thickness of more than 8 mm according to ultrasound.

EFFECT: invention provides activation of regenerative processes, promotes restoration of morphofunctional structure of endometrium, increased receptivity of endometrium, accordingly increases frequency of pregnancy and reduces risk of reproductive losses in ART programs.

1 cl, 1 dwg, 6 tbl, 3 ex