IMIDAZOLE DERIVATIVES ACTIVE TO CB1 RECEPTOR Russian patent published in 2009 - IPC C07D233/54 C07D401/12 A61K31/4164 A61P25/00 A61P3/04 A61P9/00 A61P1/00 

Abstract RU 2377238 C2

FIELD: pharmacology.

SUBSTANCE: present invention concerns compounds of formula I where R1 represents group R5S(O)2O wherein R5 represents group C1-10alkyl optionally substituted with one or more fluoro; R2a and R2b represent H or chloro; R3 represents group CONHNR7R8 wherein NR7R8 represents pyperidine-1-yl; and R4 represents group C1-3alkyl, and its pharmaceutically acceptable salts. Besides the invention concerns a pharmaceutical composition based on the compound of formula I and to application thereof in manufacturing of medicines possessing activity to CB1 receptor.

EFFECT: new imidazole derivatives expressing effective biological properties.

16 cl, 14 ex

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RU 2 377 238 C2

Authors

Cheng Lejfeng

Lindstedt-Al'Stermark Ehva-Lotte

Boije Anna Marija Persdotter

Dates

2009-12-27Published

2005-03-30Filed