FIELD: pharmaceuticals.
SUBSTANCE: invention relates to a method of producing a crystalline modification of 2-(diphenylacetyl)-1H-indene-1,3(2H)-dione, characterized by the following values of crystallographic cell parameters: space group Pna2(1): a = 8.549(2), b = 35.323 (7), c = 5.803(1)
, Z = 4. The method is carried out by crystallization from a system with the substance diphenacin microencapsulated in phospholipid capsules in the presence of solubilizers, which are a mixture of glycerol and dimethyl sulfoxide, in an aqueous solution in the presence of hydrochloric acid.
EFFECT: production of a crystalline modification of 2-(diphenylacetyl)-1H-indene-1,3(2H)-dione using renewable natural raw materials (lipids) and avoiding mother liquors with a high chloroform content.
1 cl, 2 dwg, 3 tbl, 14 ex
| Title | Year | Author | Number |
|---|---|---|---|
| POLYMORPHIC FORM OF 2-(DIPHENYLACETYL)-1H-INDENE-1,3(2H)-DIONE WITH IMPROVED RATES OF DEATH AND METHOD OF ITS PREPARATION | 2023 |
|
RU2810496C1 |
| CRYSTALLINE MODIFICATION OF 2-[(4-CHLOROPHENYL) PHENYLACETYL] -1H-INDENE-1,3(2H)-DIONE (CHLOROFACINONE) WITH INCREASED TOXICITY CHARACTERISTICS AND METHOD FOR ITS PREPARATION | 2020 |
|
RU2748259C1 |
| CRYSTALLINE MODIFICATION 2-[(4-CHLOROPHENYL) PHENYLACETYL]-1H-INDENE-1,3(2H)-DIONE (CHLOROFACINONE) AND A METHOD FOR ITS PREPARATION | 2020 |
|
RU2748131C1 |
| METHOD OF PREPARING WATER-SOLUBLE DIPHENACINE PRODUCT POSSESSING RODENTICIDE ACTIVITY | 1997 |
|
RU2130258C1 |
| RODENTICIDE | 1999 |
|
RU2144766C1 |
| RODENTICIDE COMPOSITION | 2004 |
|
RU2276494C1 |
| RODENTICIDE AGENT | 1995 |
|
RU2143803C1 |
| METHOD FOR RAT CONTROL | 1991 |
|
RU2013955C1 |
| BAIT FOR RODENT CONTROL | 0 |
|
SU1755756A1 |
| RODENTICIDE PREPARATION | 2001 |
|
RU2201676C2 |
