FIELD: biotechnology; medicine.
SUBSTANCE: antisense oligonucleotide is proposed that is capable of increasing the frequency of inclusion of exon 17 in the human MARK2 gene mRNA during the formation of the said mRNA by splicing from pre-mRNA in the cell. The antisense oligonucleotide has the sequence 5'-CGCTCAGCGAGAC-3'P, in which every second nucleotide is a locked nucleic acid (LNA) and every internucleotide bond is a phosphorothioate bond.
EFFECT: invention provides a targeted change in splicing in MARK2 gene and can be used to correct possible deregulation of splicing in MARK2 gene and, accordingly, for the production of drugs aimed at such correction.
1 cl, 1 dwg, 2 tbl, 3 ex
| Title |
Year |
Author |
Number |
| DEEP GLYCATION END PRODUCTS RECEPTOR MODULATORS AND MODULATION |
2020 |
- Uilton, Stiven
- Tomas, Merlin Kristofer
- Rozado, Karlos
- Pikering, Raelen Dzhejn
|
RU2820247C2 |
| TREATMENT OF TUMORS OF DISEASES RELATED TO THE GENOM-SUPPRESSOR BY THERAPY OF NATURAL TRANSCRIPT INHIBITION IN ANTI-SIGNIFICANT ORIENTATION REGARDING THIS GENE |
2009 |
- Kollard Dzhozef
- Khorkova Sherman Olga
|
RU2618688C2 |
| TREATING DISEASES ASSOCIATED WITH VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) BY SUPPRESSION OF NATURAL ANTISENSE VEGF TRANSCRIPT |
2009 |
- Kollard Dzhozef
- Khor'Kova Sherman Ol'Ga
|
RU2569182C2 |
| TREATMENT OF DISEASES ASSOCIATED WITH ERYTHROPOIETIN (EPO) BY NATURAL EPO ANTISENSE TRANSCRIPT INHIBITION |
2009 |
- Kollard Dzhozef
- Khorkova Sherman Olga
|
RU2620970C2 |
| TREATMENT OF TUMORS OF DISEASES RELATED TO THE GENOM-SUPPRESSOR BY THERAPY OF NATURAL TRANSCRIPT INHIBITION IN ANTI-SIGNIFICANT ORIENTATION REGARDING THIS GENE |
2009 |
- Kollard Dzhozef
- Khorkova Sherman Olga
|
RU2746478C2 |
| TARGET RNA EDITING |
2015 |
- Klein, Bart
- Platenburg, Gerardus Johannes
|
RU2711506C2 |
| NEW METHOD OF TREATING RETINITIS PIGMENTOSA |
2020 |
- Fletcher Sue
- Pitout Ianthe
- Grainok Jayna
- Wilton Steve D
- Chen Fred K
|
RU2817702C2 |
| METHOD OF PRODUCING MOUSE MODEL FOR STUDYING DUCHENNE MUSCULAR DYSTROPHY AND VERSIONS OF ITS THERAPY |
2023 |
- Aleksandra V. Bruter
- Yuliya Yu. Silaeva
- Diana S. Korshunova
- Ilchuk Leonid Albertovich
- Okulova Iuliia Dmitrievna
- Kubekina Marina Vladislavovna
- Baikova Iuliia Pavlovna
- Safonova Polina Dmitrievna
|
RU2815936C1 |
| OLIGONUCLEOTIDE FOR TREATMENT OF MUSCULAR DYSTROPHY PATIENTS |
2013 |
- Van Detekom Yudit Kristina Teodora
|
RU2674600C2 |
| TREATING SIRTIUN 1 (SIRT1)-RELATED DISEASES BY INHIBITON OF NATURAL ANTISENSE TRANSCRIPT |
2009 |
- Kollard, Dzhozef
- Khor'Kova Sherman, Ol'Ga
- Kojto, Karlush
- De Leon, Belinda
|
RU2551234C2 |
