FIELD: chemistry; pharmaceutics.
SUBSTANCE: group of inventions relates to chemistry and pharmaceutics. Object 1 is an antisense oligonucleotide targeting a nucleic acid sequence SEQ ID NO: 1, to inhibit expression of a gene encoding Cav3.1, where the antisense oligonucleotide is capable of hybridisation with a nucleic acid sequence SEQ ID NO: 1 and has length of 16 to 25 nt. Objects 2-7 are pharmaceutical compositions containing said antisense oligonucleotide, for treating Parkinson's disease, depression, essential tremor, epilepsy, anxiety disorder, recovery of consciousness in an unconscious patient.
EFFECT: specific inhibition of Cav3.1 gene expression by an antisense oligonucleotide with minor side effects when administered in vivo.
18 cl, 13 dwg, 3 tbl, 9 ex
| Title | Year | Author | Number |
|---|---|---|---|
| LYSE VARIANT AND METHOD FOR PRODUCING L-ARGININE USING SAME | 2022 |
|
RU2840267C2 |
| MICROORGANISM OF GENUS CORYNEBACTERIUM, PRODUCING L-ARGININE, AND METHOD OF PRODUCING L-ARGININE USING SAID MICROORGANISM | 2022 |
|
RU2837670C2 |
| MICROORGANISM HAVING DNA-BINDING TRANSCRIPTION REGULATOR OF LACI FAMILY WITH WEAKENED ACTIVITY, AND METHOD FOR PRODUCING L-GLUTAMIC ACID USING IT | 2022 |
|
RU2833333C2 |
| METHOD FOR ANALYSING SOMATIC MUTATIONS IN IDH1 AND IDH2 GENES USING LNA-BLOCKING PCR AND HYBRIDISATION WITH BIOLOGICAL MICROCHIP | 2024 |
|
RU2839291C1 |
| METHOD FOR GENOTYPING NEISSERIA GONORRHOEAE ISOLATES ON BIOLOGICAL MICROCHIP | 2023 |
|
RU2816767C1 |
| ANTIGENIC PEPTIDES FOR PREVENTION AND TREATMENT OF B-CELL HEMOBLASTOSIS | 2020 |
|
RU2833806C1 |
| METHOD FOR DETERMINING THE SUBLINES OF THE TUBERCULOSIS CAUSATIVE AGENT OF THE L2 beijing LINE ON BIOLOGICAL MICROCHIPS | 2022 |
|
RU2790296C1 |
| NOVEL VERSION OF ACETATE METABOLISM REGULATOR A AND METHOD FOR PRODUCTION OF BRANCHED CHAIN L-AMINO ACIDS USING IT | 2022 |
|
RU2838060C2 |
| SORAFENIB-BASED COMBINATION THERAPY FOR HEPATOCELLULAR CARCINOMA | 2022 |
|
RU2800071C1 |
| METHOD FOR MULTIPLEX IDENTIFICATION OF 52 GENETIC MARKERS OF ECONOMICALLY VALUABLE FLAX TRAITS | 2023 |
|
RU2826718C1 |
