FIELD: biotechnology.
SUBSTANCE: method of increasing the expression of PTEN polynucleotide in cells or tissues of a patient in vivo or in vitro comprising contacting mentioned cells or tissues with at least one antisense oligonucleotide of a length of 10-30 nucleotides targeted by a natural antisense polynucleotide PTEN selected from SEQ ID NOs: 14 and 15; Thereby increasing the expression of the PTEN polynucleotide in the cells or tissues of the patient in vivo. Also an appropriate oligonucleotide, a composition comprising it, and a method for preventing or treating a disease associated with at least one PTEN polynucleotide and/or at least one encoded product with the oligonucleotide are provided.
EFFECT: invention extends the arsenal of agents for the treatment of the prevention or treatment of a disease associated with at least one PTEN polynucleotide or at least one encoded by the product.
20 cl, 9 dwg, 1 tbl, 2 ex
