FIELD: biotechnology.
SUBSTANCE: invention represents the use of PH20 variant containing one or more substitutions of amino acid residues selected from the group consisting of S343E, M345T, K349E, L353A, L354I, N356E and I361T in wild-type PH20 having the amino acid sequence SEQ ID NO: 1, to obtain a pharmaceutical composition that is thermostable for a long time, including: (a) a medicinal product; and (b) the said PH20 variant, and where the medicinal product is not pembrolizumab.
EFFECT: invention makes it possible to obtain thermostable compositions containing PH20 variant.
26 cl, 20 dwg, 12 tbl, 28 ex
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