FIELD: biotechnology.
SUBSTANCE: invention represents the use of PH20 variant containing one or more substitutions of amino acid residues selected from the group consisting of S343E, M345T, K349E, L353A, L354I, N356E and I361T in wild-type PH20 having the amino acid sequence SEQ ID NO: 1, to obtain a pharmaceutical composition that is thermostable for a long time, including: (a) a medicinal product; and (b) the said PH20 variant, and where the medicinal product is not pembrolizumab.
EFFECT: invention makes it possible to obtain thermostable compositions containing PH20 variant.
26 cl, 20 dwg, 12 tbl, 28 ex
Title |
Year |
Author |
Number |
NEW VERSIONS OF HYALURONIDASE WITH IMPROVED STABILITY AND THE PHARMACEUTICAL COMPOSITION CONTAINING THEM |
2021 |
- Park, Soon Jae
- Chung, Hye-Shin
- Lee, Seung Joo
- Kim, Kyuwan
- Song, Hyung-Nam
|
RU2811464C2 |
ANTIBODY-LIKE BINDING PROTEINS WITH DOUBLE VARIABLE REGIONS HAVING CROSS-CROSS ORIENTATION OF BINDING REGIONS |
2012 |
- Baurin, Nicolas
- Beil, Christian
- Corvey, Carsten
- Lange, Christian
- Li, Danxi
- Mikol, Vincent
- Steinmetz, Anke
- Rao, Ercole
|
RU2823693C2 |
NEW VERSIONS OF HYALURONIDASE AND A PHARMACEUTICAL COMPOSITION CONTAINING THEM |
2019 |
- Park, Soon Jae
- Chung, Hye-Shin
- Lee, Seung Joo
- You, Sun-Ah
- Song, Hyung-Nam
- Lee, Chang Woo
|
RU2766680C1 |
VERSIONS OF THE FC-DOMAIN WITH MODIFIED ABILITIES TO BIND TO FCRN |
2015 |
|
RU2730592C2 |
VARIANTS OF FC-REGION WITH MODIFIED ABILITY TO BIND TO FCRN AND WITH PRESERVED ABILITY TO BIND WITH PROTEIN A |
2015 |
- Shkolaut Aleksander
- Shlotauer Tilman
|
RU2727639C2 |
METHOD OF PRODUCING A POLYPEPTIDE HETEROMULTITERS |
2014 |
- Igava Tomoyuki
- Katada Khitosi
- Mimoto Futa
|
RU2730594C2 |
PREDICTION OF RISK OF DEVELOPMENT OF UNDESIRED REACTION RELATED TO ADMINISTRATION OF ANTIBODY TO ALK2 AND CAPABILITY OF RESPONDING TO TREATMENT WITH ANTIBODY TO ALK2 |
2019 |
- Katagiri Takenobu
- Tsukamoto Sho
- Kumagai Keigo
- Tsuji Shinnosuke
|
RU2783762C2 |
METHOD FOR PRODUCING A POLYPEPTIDE HETEROMULTIMER |
2014 |
- Igawa Tomoyuki
- Katada Hitoshi
- Mimoto Futa
|
RU2758952C1 |
ANTI-IL31 ANTIBODIES FOR VETERINARY USE |
2018 |
- Li, Shyr Jiann
- Nguyen, Lam
- Zhan, Hangjun
|
RU2795485C2 |
ANTIBODY TO TIGIT AND ITS USE |
2019 |
- Shi, Sinchzhen
- Chzhan, Pan
- Lyu, Tszyuntszyan
|
RU2786434C2 |