FIELD: pharmaceuticals.
SUBSTANCE: invention relates to the crystalline form of 1-(2-(1Н-imidazo-4-yl)ethyl)piperidin-2,6-dione characterized by the positions of the peaks in the powder X-ray diffraction pattern 2, 2θ, deg.: 16.3±0.2, 23.8±0.2 и 24.5±0.2. The crystalline form of 1-(2-(1H-imidazol-4-yl)ethyl)piperidin-2,6-dione is also characterized by the orthorhombic system of the crystal lattice and the sizes of the edges of the crystal cell,
(angstrom): 9.5±0.3, 15.0±0.3 и 15.0±0.3. The invention also relates to a pharmaceutical composition and medicinal product for the treatment and/or prevention of cough, containing a crystalline form of 1-(2-(1H-imidazol-4-yl)ethyl)piperidine-2,6-dione according to the invention in a therapeutically effective amount and at least one pharmaceutically acceptable excipient.
EFFECT: increased stability, decreased hygroscopicity, increased therapeutic effectiveness of the form of 1-(2-(1H-imidazol-4-yl)ethyl)piperidine-2,6-dione.
12 cl, 3 dwg, 5 tbl, 6 ex
