FIELD: organic; medicinal chemistry.
SUBSTANCE: invention relates to compounds of general formula A and B, where R1 = hydrogen atom, fluorine or amino group — 3-NH2 or 4-NH2; R2 = amino group of 2-NH2 or 4-NH2, which are amino derivatives of 4,6 (5,7)-diaryl-substituted pyrimidines or [1,2,4]triazolo[1,5-a]pyrimidines.
The compounds can be used to treat patients with cancer, neurodegenerative diseases, tuberculosis, COVID-19, type 2 diabetes and other diseases caused by increased activity of immune cells.
EFFECT: creation of new biologically active compounds of formula A and B that suppress the formation of inflammatory mediators nitric oxide NO and interleukin 6.
1 cl, 3 dwg, 2 tbl, 9 ex
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