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2 813 436

(13)

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IPC

A61M1/34(2006-01-01)

G01N33/573(2006-01-01)

A61K39/395(2006-01-01)

A61K31/573(2006-01-01)

A61P7/04(2006-01-01)

(21) (22)

Application

2023105413, 2023-03-09

(24)

Start date

2023-03-09

(22)

Actual filing date

2023-03-09

(45)

Published

2024-02-12

(72)

Inventor

Klebanova Elizaveta EvgenevnaGalstyan Gennadij MartinovichMamleeva Svetlana YurevnaFidarova Zalina TajmurazovnaBessmertnyj Dmitrij Konstantinovich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Meditsinskij Issledovatelskij Tsentr Gematologii" Ministerstva Zdravookhraneniya Rossijskoj Federatsii

METHOD OF TREATING ACQUIRED THROMBOTIC THROMBOCYTOPENIC PURPURA, BASED ON ACHIEVING TARGET VALUES OF ACTIVITY OF ADAMTS13 IN BLOOD PLASMA Russian patent published in 2024 - IPC A61M1/34 G01N33/573 A61K39/395 A61K31/573 A61P7/04

Abstract RU 2813436 C1

FIELD: medicine; hematology.

SUBSTANCE: invention can be used for acquired thrombotic thrombocytopenic purpura. Treatment is based on plasma exchange (TPE) procedures, application of glucocorticosteroids, rituximab and caplacizumab. Rituximab therapy is started after an increase in the blood platelet count of ≥ 150×10⁹/l and termination of plasma exchange procedures. Duration of caplacizumab therapy is determined by achieving ADAMTS13 activity in blood plasma of ≥ 20 %.

EFFECT: method enables reducing the risk of disease recurrences by eliminating the possibility of rituximab elimination during TPE, as well as reducing the duration of the therapy by measuring ADAMTS13 activity in blood plasma.

7 cl, 5 dwg, 3 ex

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RU 2 813 436 C1

Authors

Klebanova Elizaveta Evgenevna

Galstyan Gennadij Martinovich

Mamleeva Svetlana Yurevna

Fidarova Zalina Tajmurazovna

Bessmertnyj Dmitrij Konstantinovich

Dates

2024-02-12—Published

2023-03-09—Filed