FIELD: pharmaceuticals.
SUBSTANCE: group of inventions relates to a compound selected from compounds of formula I:
and their pharmaceutically acceptable salts, refers to a pharmaceutical composition useful for targeting the spliceosome and mutation therein, containing an effective amount of the compound and/or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier, also relates to the use of a compound and/or a pharmaceutically acceptable salt thereof or a pharmaceutical composition for the preparation of a medicinal products for the treatment of cancer selected from the following group: myelodysplastic syndrome, chronic lymphocytic leukemia, chronic myelomonocytic leukemia, acute myeloid leukemia, colon cancer, pancreatic cancer, endometrial cancer, ovarian cancer, breast cancer, uveal melanoma, cancer stomach, cholangiocarcinoma and lung cancer.
EFFECT: group of inventions provides for the development of a medicinal product having the structure of a compound of formula I and a targeted effect on the spliceosome.
26 cl, 15 tbl, 205 ex
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