FIELD: pharmaceuticals.
SUBSTANCE: invention relates to a pharmaceutical composition comprising an effective amount of a compound selected from a compound of formulas 1, 2, 3, 4 or a pharmaceutically acceptable salt thereof intended for the treatment of cancer that is sensitive to the action of an agent having splicing inhibitory activity, where the cancer is selected from pulmonary adenocarcinoma (LUAD), uterine endometrial carcinoma (UCEC), massive progressive fibrosis (PMF), prostate adenocarcinoma (PRAD), colon adenocarcinoma (COAD), serous cystadenocarcinoma of the ovary (OV), cutaneous melanoma (SKCM), squamous cell carcinoma lung cell (LUSC), gastric adenocarcinoma (STAD), glioblastoma multiforme (GBM), low-grade brain glioma (LGG) and diffuse B-cell lymphoma (DLBCL), wherein the pharmaceutical composition further contains one or more pharmaceutically acceptable carriers. The invention also relates to the use of compounds of formula 1, 2, 3, 4 for the preparation of the said pharmaceutical composition.
EFFECT: obtaining a pharmaceutical composition that can be used in medicine as an effective agent in the treatment of oncological diseases, in particular oncological diseases for which agents targeting the spliceosome and its mutations are suitable.
15 cl, 10 dwg, 7 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| PYRIDINE COMPOUNDS OF PLADIENOLIDE AND METHODS OF USE | 2015 |
|
RU2707730C2 |
| COMBINATION INCLUDING AT LEAST ONE SPLICEOSOME MODULATOR AND AT LEAST ONE INHIBITOR SELECTED FROM BCL2 INHIBITORS, BCL2/BCLXL INHIBITORS, AND BCLXL INHIBITORS, AS WELL AS APPLICATION METHODS | 2018 |
|
RU2783239C2 |
| SOLID FORMS OF PLADIENOLIDE PYRIDINE COMPOUNDS AND METHODS FOR USE THEREOF | 2016 |
|
RU2743349C2 |
| SPECIFIC PLADIENOLIDE COMPOUNDS AND METHODS OF THEIR USE | 2019 |
|
RU2813597C2 |
| PLADIENOLIDE DERIVATIVES AS DRUGS WITH TARGETED INFLUENCE ON SPLICEOSOME FOR TREATMENT OF CANCER | 2019 |
|
RU2815064C2 |
| ANTIBODY AND DRUG CONJUGATES AS A SPLICING MODULATOR AND METHODS OF THEIR USE | 2019 |
|
RU2799438C2 |
| SUBSTITUTED BENZENE COMPOUNDS | 2013 |
|
RU2662436C2 |
| DIARYLTHIOHYDATOIC COMPOUNDS | 2007 |
|
RU2449993C2 |
| PYRIDOPYRIMIDINONE DERIVATIVES AND USE THEREOF AS AROMATIC HYDROCARBON RECEPTOR MODULATORS | 2021 |
|
RU2818954C1 |
| INHIBITORS OF NOTCH SIGNAL TRANSMISSION WAYS AND THEIR APPLICATION FOR CANCER TREATMENT | 2012 |
|
RU2631611C2 |
