FIELD: chemistry.
SUBSTANCE: invention relates to pyridine compounds of pladienolide of formulas 1–4, to pharmaceutical compositions containing similar compounds, and to methods of using said compounds as therapeutic agents.
4.
EFFECT: technical result is obtaining novel compounds and pharmaceutical compositions based thereon, which can be used in medicine for treating oncological diseases, in particular, in which agents are targeting a spliceosome and its mutations.
53 cl, 7 tbl, 10 dwg, 1 ex
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