FIELD: pharmaceutics.
SUBSTANCE: invention refers to pharmaceutics and can be used for preparing an injectable form of an antibacterial preparation based on berberine. Method for preparing the water-soluble form of the preparation based on berberine is characterized by that the solvent used is 1-methyl-2-pyrrolidone at temperature of 40 °C and with constant stirring, berberine powder is added thereto, the obtained mixture is stirred until complete dissolution, and, while continuing to stir, Cremophor EL is added as a surfactant, and after 15 minutes, while continuing to stir, adding water, bringing the volume of solution to 100 ml, with the following ratio of components, wt.%: berberine — 1–10; 1-methyl-2-pyrrolidone — 20–50; Cremophor EL — 2–10; rest is water.
EFFECT: invention provides high bioavailability of the active substance berberine due to its micellar form.
1 cl, 8 tbl, 3 ex
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