FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, in particular to a genetically modified mouse animal that expresses a humanized IL-6Rα protein, as well as to a method for its production. Also disclosed is an isolated murine embryonic stem cell for producing a murine that expresses a humanized IL-6Rα protein.
EFFECT: invention makes it possible to effectively obtain non-human animals in which one or more pathologies characteristic of non-human animals transgenic for human IL-6 are not detected.
14 cl, 3 tbl, 3 ex, 15 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| HUMANIZED IL-6 AND IL-6 RECEPTOR | 2012 |
|
RU2634417C2 |
| HUMANISED IL-15 ANIMALS | 2014 |
|
RU2674910C2 |
| HUMANIZED IL-7 RODENTS | 2013 |
|
RU2654565C2 |
| ANTIBODIES OF HIGH AFFINITY TO IL-6-RECEPTOR OF HUMANS | 2007 |
|
RU2433138C2 |
| ANIMALS WITH HUMANIZED IL-4 AND IL-4Rα | 2015 |
|
RU2788523C2 |
| ANIMALS WITH HUMANIZED IL-4 AND IL-4Rα | 2015 |
|
RU2703139C2 |
| HUMANISED MICE WITH SIRPA-IL15 NOKIN AND METHODS FOR USING THEM | 2016 |
|
RU2730599C2 |
| GENETICALLY MODIFIED NON-HUMAN ANIMALS EXPRESSING HUMAN EPO | 2015 |
|
RU2799086C2 |
| NON-HUMAN GENETICALLY MODIFIED ANIMALS EXPRESSING HUMAN EPO | 2015 |
|
RU2711744C1 |
| GENETICALLY MODIFIED MHISTOCOMPATIBILITY COMPLEX MICE | 2012 |
|
RU2783984C2 |
