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IPC

C07K16/24(2006-01-01)

C12N15/13(2006-01-01)

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Application

2015145831/10, 2015-10-26

(24)

Start date

2015-10-26

(22)

Actual filing date

2015-10-26

(45)

Published

2016-11-27

(72)

Inventor

Tillib Sergej VladimirovichNedospasov Sergej ArturovichEfimov Grigorij AleksandrovichDrutskaja Marina SergeevnaKruglov Andrej AlekseevichGorjajnova Oksana SergeevnaIvanova Tatjana Ilinichna

(73)

Holder

Federalnoe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Nauki Institut Molekuljarnoj Biologii Im. V.A. Engelgardta Rossijskoj Akademii Nauk Ran)

RECOMBINANT SINGLE-DOMAIN ANTIBODIES SPECIFICALLY BINDING HUMAN INTERLEUKIN-6, METHOD FOR THEIR PREPARING AND USING FOR DETECTION OF THIS PROTEIN Russian patent published in 2016 - IPC C07K16/24 C12N15/13

Abstract RU 2603269 C1

FIELD: biotechnology; medicine.

SUBSTANCE: present invention relates to molecular immunology, biotechnology and medicine. Recombinant variants of a single-domain antibody (VHH) are presented, which specifically binds human interleukin-6 (IL-6) and is characterized by amino acid sequences. Single-domain antibodies disclosed herein are obtained on basis of antigen-recognizing antibody domains of lamp (Lama glama).

EFFECT: present invention can find further application in diagnosing and treating IL-6-mediated diseases.

3 cl, 4 dwg

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RU 2 603 269 C1

Authors

Tillib Sergej Vladimirovich

Nedospasov Sergej Arturovich

Efimov Grigorij Aleksandrovich

Drutskaja Marina Sergeevna

Kruglov Andrej Alekseevich

Gorjajnova Oksana Sergeevna

Ivanova Tatjana Ilinichna

Dates

2016-11-27—Published

2015-10-26—Filed