FIELD: chemistry.
SUBSTANCE: invention relates to a compound of formula (I), where R1 is (1) C1-6 alkyl group, optionally substituted with from 1 to 3 substitutes selected from (a) a halogen atom, (b) C1-6 alkoxy group and (c) a phenoxy group, (2) C1-6 alkoxy group optionally substituted with 1 to 3 substituents selected from (a) a halogen atom, (b) a hydroxyl group, (c) a phenyl group, (d) a C1-6 alkoxy group, (e) an amino group, optionally mono- or disubstituted with C1-6 alkyl group, and (h) a pyridyl group, (3) an azetidinyl group optionally substituted with 1 to 3 substituents selected from (a) a hydroxyl group and (b) a C1-6 alkyl group, or (4) -NR2R3, where R2 is a hydrogen atom and R3 is a C1-6 alkyl group, optionally substituted with 1 to 3 substitutes selected from (a) a halogen atom, (b) a hydroxyl group, (c) a C3-10 cycloalkyl group optionally substituted with 1 to 3 substituents selected from a halogen atom and an amino group, (d) C1-6 alkoxy group and (e) a phenyl group optionally substituted with 1 to 3 halogen atoms; ring A is a benzene ring, a pyridine ring, a pyrimidine ring, a pyridazine ring, a pyrazine ring, each of which is optionally further substituted with 1–5 substituents selected from a pyrazolyl, pyrimidyl or pyridyl group, each of which is optionally substituted with 1 to 3 substituents selected from (a) an oxo group, (b) a C1-6 alkyl group and (c) C1-6 alkoxy group; ring B is an additionally unsubstituted cyclohexane ring; ring C is a pyrimidine ring, that is, X is N, optionally further substituted with 1 to 3 substituents selected from (1) a cyano group, (2) a C1-6 alkyl group optionally substituted with 1 to 3 halogen atoms, (3) an oxetanyloxy group optionally substituted with 1 to 3 C1-6 alkyl groups, (4) an amino group, optionally mono- or disubstituted with a substitute(s) selected from (a) a C1-6 alkyl group, optionally substituted with 1 to 3 hydroxyl groups, (b) an oxetanyl group optionally substituted with 1 to 3 C1-6 alkyl groups, (5) azetidinyl, azepanyl, oxazaspiro[3.4]octyl groups, each of which is optionally substituted with 1 to 3 substituents selected from (a) a halogen atom, (b) a hydroxyl group and (c) C1-6 alkyl group optionally substituted with 1 to 3 hydroxyl groups, (6) thienyl, pyrazolyl, pyridinyl group, each of which is optionally substituted with 1 to 3 substituents selected from (a) cyano group, (b) a halogen atom, (c) a C1-6 alkyl group optionally substituted with 1 to 3 halogen atoms and (d) C1-6 alkylsulfonyl group, or a pharmacologically acceptable salt thereof. Invention also relates to a drug preparation based on said compound.
EFFECT: novel compound and a drug preparation based thereon, which can be used in medicine for treating CDK12-mediated diseases, are obtained.
9 cl, 1 dwg, 7 tbl, 858 ex
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