TREATMENT AND PREVENTION OF ALLERGY TO HOUSE DUST MITES Russian patent published in 2024 - IPC C07K14/435 C07K14/02 C07K19/00 C12P21/02 A61K39/35 A61K47/64 A61P37/08 

FIELD: medicine.

SUBSTANCE: invention relates to the production of fusion proteins based on house dust mite allergens, and can be used in medicine in the immunotherapy of patients suffering from house dust mite allergies. A fusion protein of formula (I) is proposed: X₁-Y-X₂ (I), where X₁ and X₂ each contain four to eight allergen fragments fused to each other, wherein the said allergen fragments are derived from at least two allergens of Dermatophagoides pteronyssinus mites selected from the group consisting of Der p 1, Der p 2, Der p 5, Der p 7, Der p 21 and Der p 23, and where Y is a surface polypeptide of a virus of the hepadnavirus family or a fragment of a surface polypeptide used as a carrier protein.

EFFECT: induction of in vivo formation of antibodies directed to at least two allergens of mites of Dermatophagoides genus and inhibiting the interaction of allergen-specific IgE with their corresponding allergen, which makes it possible to reduce or even prevent allergic reactions leading to the need to treat allergies caused by allergens of mites of Dermatophagoides genus.

12 cl, 9 dwg, 3 tbl, 6 ex