ISOQUINOLINONE DERIVATIVES, METHOD FOR PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DISEASES ASSOCIATED WITH POLY(ADP-ribose)POLYMERASE-1, CONTAINING THEM AS ACTIVE INGREDIENT Russian patent published in 2024 - IPC C07D217/24 C07D401/06 C07D401/12 C07D417/12 A61K31/4709 A61K31/497 A61K31/506 A61K31/55 A61P27/02 

FIELD: chemistry.

SUBSTANCE: present invention relates to an isoquinolinone derivative of formula 1, a stereoisomer thereof or a pharmaceutically acceptable salt thereof.

formula 1, in which

L¹ is -(CH₂)₃- or -(CH₂)₂C(=O)-; Y is 4-6-membered monocyclic or 8-membered bicyclic heterocycloalkylene containing one or two nitrogen atoms, or 6-membered monocyclic heterocycloalkenylene containing one nitrogen atom; L² is a single bond, -NHCO-, -NR₂-, -O- or straight or branched C_1-4alkylene substituted with one or more substitutes selected from the group consisting of oxo and amino, R² is hydrogen or methyl; and Z is C_3-6cycloalkyl, heterocycloalkyl, which is tetrahydrofuranyl or pyrrolidinyl, phenyl or heteroaryl selected from pyridyl, pyrimidyl and thiazole; where each said cycloalkyl, heterocycloalkyl, phenyl and heteroaryl is independently unsubstituted or substituted with one or more substituents selected from the group consisting of -F, -Cl, cyano, nitro, methyl, unsubstituted or substituted with one or more fluorine, methoxy substituted with one or more fluorine, carboxy(-CO₂H), methoxycarbonyl and methylcarbonylamino. Technical result is development of PARP-1 inhibitor.

EFFECT: disclosed compounds can be effectively used to prevent or treat diseases associated with PARP-1, in particular ophthalmic diseases or disorders.

10 cl, 1 dwg, 4 tbl, 277 ex