BENZOIC ACID DERIVATIVES AS PPAR α AND PPAR λ MODULATORS Russian patent published in 2008 - IPC C07C65/24 C07C51/09 C07C59/68 C07C69/76 C07C233/78 C07C235/34 C07C275/30 C07C275/32 C07C309/66 C07C311/13 C07C323/62 C07D213/38 C07D213/40 C07C217/06 C07D233/54 C07D233/60 C07D277/20 C07D277/56 C07D307/68 A61K31/19 A61K31/192 A61K31/4164 A61K31/426 A61K31/4402 A61K31/472 A61K31/606 A61K31/185 A61K31/60 A61P3/06 A61P3/10 

FIELD: chemistry.

SUBSTANCE: in novel compounds of formula I R¹ represents phenyl, possibly substituted with phenyl or heterocyclic group, or heterocyclic group, possibly substituted with phenyl, where said heterocyclic group represents mono- or bicyclic ring, containing 4-12 atoms, of which at least one atom is selected from nitrogen, sulfur or oxygen, each phenyl or heterocyclic group possibly being substituted with one or more than one of the following groups: C_1-6alkyl group; phenylC_1-6alkyl, alkyl, phenyl or alkylphenyl group is possibly substituted with one or more than one from R^b; halogen; -OR^a; -OSO₂R^d; -SO₂R^d; -SOR^d; -SO₂OR^a; where R^a represents H, C_1-6alkyl group, phenyl or phenylC_1-6alkyl group; where R represents halogeno, -OH, -OC_1-4alkyl, Ophenyl, -OC_1-4alkylphenyl, and R^d represents C_1-4alkyl; group -(CH₂)m-T-(CH₂)n-U-(CH₂)p- is bound either in third, or in fourth position in phenyl ring, as shown with figures in formula I, and represents group selected from one or more than one of the following: O(CH₂)₂, O(CH₂)₃, NC(O)NR⁴(CH₂)₂, CH₂S(O₂)NR⁵(CH₂)₂, CH₂N(R⁶)C(O)CH₂, (CH₂)₂N(R⁶)C(O)(CH₂)₂, C(O)NR⁷CH₂, C(O)NR⁷(CH₂)₂ and CH₂N(R⁶)C(O)CH₂O; V represents O, NR⁸ or single bond; q represents 1, 2 or 3; W represents O, S or single bond; R² represents halogeno or C_1-4alkoxyl group; r represents 0, 1, 2 or 3; s represents 0; and R⁶ independently represent H or C_1-10alkyl group; R⁴, R⁵, R⁷ and R⁸ represent hydrogen atom; and to their pharmaceutically acceptable salts.

EFFECT: increase of composition efficiency.

12 cl, 31 ex