FIELD: biotechnology.
SUBSTANCE: disclosed is a method for increasing insulin secretion β-cells of pancreatic islets of Langerhans by means of thermogenetics. In β-cells deliver a genetic construct containing a promoter specific for them and a gene of human thermally activated channel TRPV1. Then β-cells are heated in a PCR machine with a certain mode of heating and cooling cycles.
EFFECT: invention enables non-invasive stimulation β-cells of pancreatic islets of Langerhans and stimulate insulin secretion.
3 cl, 2 dwg, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR TREATMENT OF PATIENTS WITH DIABETES MELLITUS | 2003 |
|
RU2240134C1 |
| METHOD OF CONTROL OF HEART RHYTHM AND REDUCTION OF INDIVIDUAL CARDIOMYOCYTES USING THERMOGENETICS | 2022 |
|
RU2802995C1 |
| USING TISSUE FACTOR INHIBITOR OR ANTAGONIST | 2003 |
|
RU2315621C2 |
| METHOD OF INDUCING TARGETED DIFFERENTIATION OF MULTIPOTENT PROGENITOR CELLS OF PANCREAS IN INSULIN-PRODUCING BETA CELLS DURING DIABETES | 2014 |
|
RU2579997C2 |
| AGONISTS OF HYPOPHYSIS ADENYLATE CYCLASE PEPTIDE-ACTIVATOR RECEPTOR-3(R3)(PACAP) AND METHODS FOR THEIR PHARMACOLOGICAL USING | 2000 |
|
RU2269354C2 |
| COMBINATION FOR REGENERATIVE THERAPY OF TYPE 1 DIABETES MELLITUS | 2018 |
|
RU2694527C1 |
| ADIPOSE STROMAL CELL DIFFERENTIATION INTO ENDOCRINE PANCREAS CELLS AND APPLICATION THEREOF | 2002 |
|
RU2351648C2 |
| METHOD FOR IMPROVING SIGNAL TRANSFER IN ISLETS OF LANGERHANS IN DIABETES MELLITUS AND IN ITS PROPHYLAXIS | 2001 |
|
RU2261096C2 |
| CELL PRODUCT OF INSULIN-PRODUCING MAMMALIAN CELLS AND USE THEREOF FOR DIABETES MELLITUS THERAPY | 2017 |
|
RU2663118C1 |
| MEDICAL PRODUCT AND FOODSTUFF OR BEVERAGE FOR PANCREAS IMPROVEMENT | 2006 |
|
RU2353368C1 |
