IMPROVED METHOD OF PRODUCING 5-CHLOROPYRIDIN-3-YL-1N-INDOLE-4-CARBOXYLATE Russian patent published in 2024 - IPC C07D213/62 C07B39/00 

Abstract RU 2816391 C1

FIELD: chemical or physical processes.

SUBSTANCE: invention relates to a method of producing 5-chloropyridin-3-yl-1H-indole-4-carboxylate, which involves esterification of indole-4-carboxylic acid and 3-hydroxy-5-chloropyridine in the presence of N, N'-dicyclohexylcarbodiimide, 1,1-carbonyldiimidazole or 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide and 4-dimethylaminopyridine in molar ratio of 1 : 1 : 1.5 : 0.1, respectively, in a medium of methylene chloride at room temperature for 8 hours according to the scheme:

the product is extracted by successive recrystallization from benzene and ethanol.

EFFECT: improved method of producing 5-chloropyridin-3-yl-1H-indole-4-carboxylate, characterized by high purity of the obtained product, which also enables to scale the technology of producing the compound.

1 cl, 1 tbl, 3 ex

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RU 2 816 391 C1

Authors

Belyaev Artur Sergeevich

Volkov Vitalij Leonardovich

Illarionov Vladimir Vladimirovich

Nikitin Oleg Mikhajlovich

Kovtun Viktor Aleksandrovich

Mosin Nikita Igorevich

Muradov Mikhail Mikhajlovich

Shevchenko Elena Viktorovna

Predtechenskij Aleksandr Borisovich

Dates

2024-03-28Published

2023-02-06Filed